This is a toolbox deck that is based around artifacts and its namesake card, Transmute Artifact. It uses Transmute Artifact and a bunch of different artifacts, mostly one ofs, to always be able to have a good answer to whatever the opponent is doing. As this format contains a lot of powerful artifacts the possibilities are endless, but some of the more common ones are Mirror Universe, Triskelion, Icy Manipulator, Jayemade Tome, Ivory Tower and City in a Bottle.

The two most common ways to build this deck is either mono blue or black and blue. The main reason for playing black is the card Guardian Beast. The beast helps you keep your artifacts intact by making them indestructible, but it also gives you access to two powerful combos. The first combo is with Chaos Orb as it lets you flip the orb without the orb being destroyed. The second combo is with Nevinyrral's Disk and lets you blow up all of your opponents permanents while all your artifacts, including the disk, stays on the table.